Endocrine Abstracts

Growth hormone (GH) and insulin like growth factor 1 (IGF-I) modulate and stimulate angiogenesis and endothelial function. Excess of GH, as in acromegaly, is associated with cardiovascular morbidity and mortality, which is reversible after normalization of IGF-I and GH. Diabetes mellitus (DM) is a common comorbidity in acromegaly, but the prevalence of diabetes retinopathy in patients with acromegaly is unknown. Also, the roles of GH and IGF-I in diabetes retinopathy are not f...